A rising star in Aesthetic Field - PDRN Polydeoxyribonucleotide

PDRN (polydeoxyribonucleotide) is a mixture of deoxyribonucleotides derived from a controlled purification process of Salmon Trout or Chum Salmon sperm DNA, ensuring its safety and stability. PDRN activates the adenosine A_2A receptors and generates nucleotides that can contribute to DNA formation, thus having a tissue repairing, wound healing, and anti-aging effect. Therefore, it is widely used in mesotherapy & dermal fillers.

Mechanism of Action

1. Activation of adenosine A_2A Receptor Adenosine activates four distinct adenosine receptors indicated as A₁, A_2A, A_2B, and A₃. The A_2A receptor plays a central role in modulating inflammation, oxygen consumption, ischemia, cell growth, and angiogenesis. PDRN can generate active deoxyribonucleotides, nucleosides, and bases, exerting their pharmacological effects and activating the A_2A receptor. PDRN interacting with the A_2A receptor provides a complete tissue regeneration and wound-healing effect.

2. DNA synthesis salvage pathway

The internalization of PDRN-derived nucleotides accompanied cell growth to offer purine and pyrimidine rings for the “salvage pathway.” Damaged or hypoxic tissue often cannot undergo the DNA “de novo” synthesis. Under these conditions, salvage pathways operate to recover bases and nucleosides generated from the breakdown of DNA and RNA. The salvaged bases can then be transformed into nucleotides and reincorporated into DNA. PDRN generates nucleotides and nucleosides that can contribute to DNA formation, offering a faster tissue regeneration and wound healing effect.

Efficacy experiments

【Anti-aging】